曹登峰主任醫師
北京大學腫瘤醫院病理科
曹登峰，男，教授，主任醫師，博士生導師, 病理科主任，病理教研室主任，北京市2012年海外高層次人才計劃(海聚計劃)入選者。 1988年就讀于北京協和醫學院8年制臨床醫學專業，1996年畢業獲得醫學博士學位(M.D.)，同年赴美留學，2001年美國University Of Pittsburgh分子發育細胞生物學博士研究生畢業，獲得理學博士學位(Ph.D.)。 2001年-2005年在美國約翰霍普金斯大學醫學院附屬約翰霍普金斯醫院(The Johns Hopkins Hospital，該院一直是美國排名第1到2名的綜合醫院) 病理學系做住院醫生(resident in anatomic and clinical pathology)，期間表現突出獲得Joseph Eggleston外科病理學獎。2005-2006年在約翰霍普金斯醫院病理系在世界著名的泌尿生殖病理學家Dr. Jonathan Epstein(2004年《世界衛生組織泌尿系統和男性生殖器官腫瘤病理學和遺傳學》主編之一)的指導下從事外科病理高級亞專科訓練, 同時強化泌尿系統和男性生殖系統病理的學習。在2001-2006年期間，還跟隨世界著名的胰腺病理學家Dr. Ralph Hruban (2010年《世界衛生組織消化系統腫瘤分類》的主編之一) 系統地學習胰腺病理。2006-2007年在美國約翰霍普金斯醫院病理系跟隨世界著名的婦科病理學家Dr. Robert Kurman (婦產科病理《Blaustein’s Pathology of the Female Genital Tract》的主編， 2013年《世界衛生組織婦科腫瘤分類》的主編之一)系統地學習婦產科病理。 2007-2011和2012年6-8月在美國圣.路易斯華盛頓大學醫學院(Washington University School of Medicine in Saint Louis)& 巴恩斯-猶太人醫院(Barnes-Jewish Hospital，2012年美國綜合醫院排名第六)病理系擔任病理醫生(attending pathologist), 助理教授(assistant professor)，副教授(associate professor), 從事外科和婦產科臨床病理的診斷，教學和科研，提供婦產科和泌尿生殖系統及胰腺疑難病理的會診，指導和訓練病理住院醫生和亞專科病理醫生，同時任免疫組織化學科研實驗室主任。 2011年8月歸國擔任北京大學腫瘤醫院病理科主任，教授，主任醫師，博士生導師，病理教研室主任，2012年入選北京市海外高層次人才計劃(海聚計劃)。從事腫瘤病理的臨床診斷，教學和科研工作。臨床病理診斷專長是腫瘤病理，提供腫瘤疑難病理的會診,特別擅長婦產科病理，泌尿系統病理，生殖細胞腫瘤病理和胰腺病理。科研方面從事腫瘤病理的形態學, 發病機理和腫瘤標志物的研究，已經發表56篇SCI論文，在世界上首先發現SALL4是最敏感的生殖細胞腫瘤標志物，并系統地研究了另外一個生殖細胞腫瘤標志物LIN28，使生殖細胞腫瘤特別是卵黃囊瘤的病理診斷難題得以最后解決。 曹登峰教授目前是4家國際學術雜志的編委會專家(editorial board member)，中華病理學會女性生殖系統病理專業學組專家，美國病理學會(College of American Pathologists)和國際泌尿病理學會(International Association of Urologic Pathology)的高級會員(fellow)，美國加拿大病理學會(United States and Canadian Academy of Pathology)會員，國際華人病理協會(International Association of Chinese Pathologists)會員，2010-2011年曾任國際華人病理協會主席。 發表的科研論文(截至2012年7月)： 1.Kunkel J, Peng Y, Tao Y, Krigman H, Cao D. Presence of sarcomatous component outside the ovary is an adverse prognostic factor for primary ovarian mixed mesodermal tumor: a clinicopathologic study of 47 cases. Am J Surg Pathol. 2012;36(6):831-7. 2.Hamilton NA, Liu TC, Cavatiao A, Mawad K, Chen L, Strasberg SS, Linehan DC, Cao D, Hawkins WG. Ki-67 predicts disease recurrence and poor prognosis in pancreatic neuroendocrine neoplasms. Surgery. 2012;152(1):107-13. 3.Hudson J, Cao D, Vollmer RD, Humphrey PA. Foamy Gland Adenocarcinoma of the Prostate: Incidence, Gleason Grade, and Early Clinical Outcome. Hum Pathol. 2012;43(7):974-9 4.Wang-Gillam A, Ben-Josef E, Cao D, Chung E, Khan A, Lim KH, Linehan DC. Neoadjuvant Therapy of Pancreatic Cancer: The Emerging Paradigm? Oncologist. 2012;17(2):192-200. 5.Xu M, Rettig M, Sudlow G, Wang B, Akers W, Cao D, Mutch D, Dipersio J, Achilefu S. I Preclinical evaluation of mab CC188 for ovarian cancer imaging. Int J Cancer. 2011 Nov 30. doi: 10.1002/ijc.27380. [Epub ahead of print] 6.Iczkowski KA, Montironi R, Cao D, Magi-Galluzzi C, Lucia MS. Pathology update for urologists. Prostate Cancer. 2011;2011:183761. 7.Abbosh PH, Grubb RL III, Cao D, Humphrey PA. Hybrid Renal Tumors in Birt-Hogg-Dubé Syndrome. J Urol. 2011;186(6):2413-4. 8.Cao D, Zhang J, Wu Z, Qiu G. Calcitonin Enhanced Lumbar Spinal Fusion in a New Zealand Rabbit Model: A Study with Morphologic and Molecular Analysis. 9.Cao D, Humphrey PA. Yolk Sac Tumor of the Testis.J Urol. 2011;186(4):1475-6. 10.Xue D, Peng Y, Wang F, Allan RW, Cao D. RNA-binding protein LIN28 is a sensitive immunohistochemical marker of ovarian primitive germ cell tumors. Histopathology 2011;59：452–459. 11.Jeung JA, Cao D, Selli BW, Clapp WL, Oliai BR, Parwani AV, Allan RW. Primary Renal Carcinoid Tumors: Evaluation of PAX-2 and PAX-8 Expression with Emphasis on Novel Immunohistochemical Findings. Human Pathol. 2011;42(10):1554-61. 12.曹登峰，霍麗明，王鵬。美國病理住院醫師培訓的經驗和借鑒。中華病理學雜志，2011年第40卷第6期第430-432頁。 13.Cao DHumphrey PA,Gao F, Tao Y, Kibel AS. The linear length of positive margin in radical prostatectomy is predictive of biochemical recurrence in patients with prostate cancer. Urology. 2011;77(6):1409-14. , 14.Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N, Akhi S, Li J. RNA-binding protein Lin28 is a marker for testicular germ cell tumors. Hum Pathol. 2011:42(5):710-8. 15.Cao D, Liu A, Wang F, Allan RW, Mei K, Peng Y, Du J, Guo S, Abel TW, Lane Z, Ma J, Rodriguez M, Akhi S, Dahiya N, Li J. RNA-binding protein Lin28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol. 2011;24(2):288-96. 16.Han S, Cao D, Molberg KH, Sarode V, Rao R, Sutton LM, Peng Y. Hormone Receptor Status Rather Than HER-2 Status is Significantly Associated with Increased Ki67 and p53 Expression in Triple-Negative Breast Carcinomas, and High Expression Level of Ki67 but not p53 is Significantly Associated with Axillary Nodal Metastasis in Triple-Negative and High Grade Non-Triple Negative Breast Carcinomas. Am J Clin Pathol. 2011;135(2):230-7. 17.SuttonLM, HanJS, MolbergKH, SarodeVR, Cao D, SailorsJ, PengY. Intratumoral Expression Level of Epidermal Growth Factor Receptor and Cytokeratin 5/6 is Significantly Associated with Nodal and Distant Metastases in Patients with Basal-like Triple-negative Breast Carcinoma. Am J Clin Pathol. 2010;134(5):782-7. 18.Wang P, Li J, Allan RW, Guo CC, Peng Y, Cao D. Expression of UTF1 in primary and metastatic testicular germ cell tumors. Am J Clin Pathol. 2010;134 (4):604-612. 19.Cao DVoller RT, Luly J, Jain S, Roytman TM, Ferris CW, Hudson MA. Comparison of 2004 WHO and 1973 WHO Grading Systems for Predicting Long-term Prognosis in Urothelial Carcinoma (UC) Patients. Urology. 2010;76(3):593-9., 20.Cao D, Lane Z, Allan RW, Wang P, Guo CC, Li J. TCL1 is a novel diagnostic marker for intratubular germ cell neoplasia and classic seminoma. Histopathology 2010;57(1):152-7. 21.Lindberg MR, Fisher C, Cao D, Cheville JC, Folpe AL. Leiomyosarcoma of the urinary bladder: a clinicopathologic study of 34 cases, with comparison of the FNCLCC, NCI, and Mayo grading systems. J Clin Pathol. 2010;63(8):708-13. 22.Shi H, Cao D, Wei L, Sun L, Guo A. Inflammatory angiomyolipomas of the liver: aclinicopathologic and immunohistochemical analysis of five cases. Ann Diagn Pathol. 2010;14(4):240-6. 23.Cao D, Kibel AS, Gao F, Tao Y, Humphrey PA. The Gleason score of tumor at themargin in radical prostatectomy is predictive of biochemical recurrence. Am J Surg Pathol. 2010;34(7):994-1001. 24.Shi H, Wang Chun, Wei L,Sun L, Cao D. Malignant mesenchymoma of the thyroid: one case report and literature review. Tumori 2010;96: 345-348. 25.Liu A, Cheng L, Du J, Peng Y, Allan RW, Wei L, Li J, Cao D. Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primarymediastinal germ cell tumors. Am J Surg Pathol. 2010;34(5):697-706. 26.Yaskiv O, Cao D, Humphrey PA. Microcystic adenocarcinomas of the prostate: a variant of pseudohyperplastic and atrophic patterns. Am J Surg Pathol.2010 ;34(4):556-61 27.Cao DBegum S, Ali SZ, Westra WH. Expression of P16 in benign and malignant cystic squamous lesions of the neck. Hum Pathol. 2010;41(4):535-9., 28.Shi H, Cao D, Wei L, Sun L, Guo A. Primary choriocarcinoma of the liver: a clinicopathologic study of 5 cases in males. Virchows Arch. 2010;456(1):65-70 29.Mei K, Liu A, Allan RW, Wang P, Lane Z, Abel TW, Wei L, Cheng H, Guo S, Peng Y, Rekheja D, Wang M, Ma J, Rodriguez M, Li J, Cao D. Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases. Mod Pathol. 2009; 22(12): 1628-36. 30.Wang F, A Liu, Peng Y, Rakheja D, Wei L, Xue D, Allan RW, Molberg KH, Li J, Cao D. Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3. Am J Surg Pathol. 2009; 33(10): 1529-1539. 31.Kibel AS, Dehdashti F, Matthew K, Aleksandra K, Robert L Grubb, Humphrey P, Siegel C, Cao D, Gao F, Siegel BA. Prospective Study Of Fdg- Pet/Ct For Staging Of Muscle-Invasive Bladder Carcinoma. J Clin Oncol. 2009; 27(26): 4314-20. 32.Cao D, Li J, Guo CC, Allan RW, Humphrey PA. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol. 2009; 33: 1065-1077. 33.Cao D, Humphrey PA, Allan RW. SALL4 is a novel sensitive and specific marker of metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumor. Cancer. 2009; 115(12): 2640-51. 34.Cao D, Guo S, Allan RW, Molberg KH, Peng Y. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009; 3(6): 894-904. 35.Arroyo M, Podda A, Cao D, Rodriguez M. Placental Site Trophoblastic Tumor in the Ovary of a Young Child with Isosexual Precocious Puberty. Pediatr Dev Pathol. 2009; 12(1): 73-76. 36.Cao D, PolyakK, HalushkaMK, NassarH, KouprinaN, Iacobuzio-DonahueC, WuX, SukumarS, HicksJ, De MarzoA and ArganiP.Serial Analysis of Lobular Carcinoma in situ identified down of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008; 10(5): R91. 37.Cheung M and Cao D. Colonic type adenocarcinoma arising in a primary retroperitoneal mature cystic teratoma. Pathol Int. 2008; 58(12): 792-6. 38.Cao D, Ashfaq R, Goggins MG, Hruban RH, Kern SE and Iacobuzio-Donahue CA. Differential Expression of Multiple Genes in Association with MADH4/DPC4/SMAD4 Inactivation in Pancreatic Cancer. Int J Clin Exp Pathol 2008; 1(6): 510-517. 39.Lollar K, Farrag TY, Cao D, Niparko J, Tufano RP. Langerhans cell histiocytosis of the thyroid gland. Am J Otolaryngol. 2008; 29(3): 201-4. 40.Cao D, Tsangaris TN, Kouprina N, Vang R, Argani P. The Superficial Margin of the Skin-Sparing Mastectomy for Breast Carcinoma: Factors Predicting Involvement and Efficacy of Additional Margin Sampling. Ann Surg Oncol. 2008; 15(5): 1330-40 41.Lai V, Farrag TY, Cao D, Aygun N, Boahene K, Tufano RP. Synovial sarcoma of the infratemporal fossa. Am J Otolaryngol. 2007; 28(6): 444-7. 42.Lee KM, Cao D (co-first authorship), Itami A, Pour PM, Hruban RH, Maitra A, Ouellette MM. Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia. Histopathology. 2007; 51(4): 539-46. 43.Cao D, Zhang Q, Wu LS, Salaria SN, Winter JW, Hruban RH, Goggins MS, Abbruzzese JL, Maitra A, Ho L. Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. Mod Pathol. 2007; 20(5): 570-8. 44.Cao D, Antonescu C, Wong G, Winter J, Maitra A, Adsay NV, Klimstra DS, Hruban RH. Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations. Mod Pathol. 2006; 19(9): 1157-63. 45.Cao D, Lin C, Woo SH, Vang R, Tsangaris T and Argani P. Separate Cavity Margin Sampling At The Time of Initial Breast Lumpectomy Significantly Reduces The Need For Re-excisions. Am J Surg Pathol. 2005; 29 (12): 1625-32. 46.Cao D, Wilentz R, Abbruzzese J, Ho L and Maitra A. Aberrant expression of maspin in idiopathic inflammatory disease is associated with disease activity and neoplastic transformation. Int J Gastrointest Cancer. 2005; 36(1): 39-46. 47.Begum S, Cao D and Westra W. Tissue distribution of HPV 16 DNA integration in patients with tonsillar carcinoma as visualized by HPV 16 in situ hybridization and p16 immunohistochemistry. Clin Cancer Res. 2005; 11 (16): 5694-9. 48.Cao D, Maitra A, Saavedra JA, Klimstra DS and Hruban RH. Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms-additional evidence of different genetic pathways. Mod Pathol. 2005; 18 (6): 752-61. 49.Cao D, Srodon M, Montgomery EA and Kurman RJ. Lipomatous variant of angiomyofibroblastoma-report of two cases and review of the literature. Int J Gynecol Pathol. 2005; 24(2): 196-200. 50.Cao D, Hafez M, Berg K and Epstein JI. Little or no residual cancer on radical prostatectomy following diagnosis of cancer on needle biopsy-vanishing cancer or switched specimens? A microsatellite analysis of biopsy and radical prostatectomy specimen identity. Am J Surg Pathol. 2005; 29(4): 467-473. 51.Cao D, Ji H and Ronnett BM. Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumor from metastatic pancreatic mucinous carcinomas in ovary. Int J Gynecol Pathol. 2005; 24(1): 67-72. 52.Singer G, Stohr R, Cope L, Dehari R, Hartmann A, Cao DF, Wang TL, Kurman RJ and Shih IM. Patterns of p53 Mutations Separate Ovarian Serous Borderline Tumors and Low- and High-grade Carcinomas and Provide Support for a New Model of Ovarian Carcinogenesis: A Mutational Analysis With Immunohistochemical Correlation. Am J Surg Pathol. 2005; 29(2): 218-224. 53.Cao D, Hustinx S, Sui S, Bala P, Sato N, Martin S, Maitra A, Murphy KM, Cameron JL, Yeo CY, Kern SE, Goggins M, Pandey A, and Hruban RH. Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags. Cancer Biol Ther. 2004; 3(11): 1081-9. 54.Hustinx S, Cao D, Sato N, Martin S, Fukushima N, Maitra A, Cameron JL, Yeo CY, Kern SE, Goggins M, Pandey A, and Hruban RH. Identification of novel differentially expressed gene in pancreatic ductal adenocarcinoms through serial analysis of gene expression. Cancer Biol Ther. 2004; 3(12): 1254-1261. 55.Parwani A, Cao Dand Epstein JI. Pathology quiz case: a 35 year-old man with hematuria. Arch Pathol Lab Med. 2004; 128(8): e104-6. . 56.Wang LF, Zhu HD, Miao SY, Cao DF, Wu YW, Zong SD and Koide SS. Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene. Arch Androl. 1999; 42(2): 71-84. 57.高穎，朱海東，曹登峰，盛齊，繆時英，王琳芳。一種新的睪丸特異核孔蛋白基因特性的研究。中國醫學科學院學報1999年第21卷第02期第81-87頁。 58.張梅林, 周雪峰, 曹登峰, 繆時英, 吳燕婉, 邢志軍, 宗書東, 王琳芳. 一種與不育有關的人精子蛋白質的組織特異性及表達. 中國醫學科學院學報, 1999年第21卷第03期第166-169頁。
腫瘤病理診斷，尤其是婦產科病理診斷，泌尿系統病理診斷、生殖系統病理診斷，胰腺疾病病理診斷?
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